The departments at Mayflower High are grouped into faculties. The faculty structure is shown below:

Business and Vocational (Business & Vocational and ICT)
Design and Technology (Design & Technology)
Expressive Arts (Art, Drama, Music and P.E.)
Science (Science)
Mathematics (Mathematics)
English (English)
M.F.L (M.F.L.)
Humanities (Geography, History, RS)